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Details of LRI
History of research subjects
History of research subjects
This is the list of research subjects under JCIA LRI program.

Blue-colored background shows the research period of each subject.
You can jump to the corresponding reports by a click of pdf icon on the list.
Annual reports will be issued in every June, and this list will be renewed accordingly.
NAME TITLE 2012/11-2013/10 2013/11-2015/2 2015/3-2016/2 2016/3-2017/2 2017/3-2018/2 2018/3-2019-2 2019/3-2020/2 2020/3-2021/2
12_S01-01 Akihiro Tokai Probabilistic Exposure Evaluation Model for Relatively Small-scale
Occupational Workplace
pdf pdf pdf
12_S01-02 Hiroshi Yamazaki Human physiologically-based pharmacokinetic modeling of@industrial chemicals with chimeric mice with humanized liver pdf pdf pdf
12_S01-03 Kohji Aoyama Establishment of animal testing for the prediction of respiratory sensitizing potential of chemicals pdf pdf pdf
13_S01-01 Masaharu Seno Development of the Novel Method with iPSCs to Assess Chemical Compounds for the Risk of CSC Induction pdf pdf pdf pdf
16_S01-01 Bin-Le Lin Advanced system development for the hazard predicition and the environmental risk assessment/management of chemical substances
Subtitle: Development of the sophisticated basis tool for environmental hazard prediction
pdf pdf
16_S01-02 Toshihiko Kasahara Prediction method (Amino acid Derivative Reactivity Assay: ADRA) for skin sensitization using novel lysine and cysteine derivatives pdf pdf
12_S02-01 Yasuo Yoshioka Evaluation of the relationship between physicochemical properties
and biodistribution of nanomaterials
pdf pdf
13_S02-01 Hitoshi Iwahashi Study on the cellular and environmental effect related with solubility
of industrial nanomaterials
pdf pdf
13_S03-01 Kaeko Kamei Study on the mechanism of sick building syndrome and
development of risk assessment system utilizing Drosophila
pdf pdf pdf
15_S03-01 Takayuki Yoshimoto Establishment of in vitro evaluation system for the prediction of
respiratory sensitizing potential of chemicals
pdf pdf pdf pdf
12_S04-01 Tatsuya Takagi Development of in silico Prediction Model on Environmental Fate of Chemical Substances pdf pdf
12_PT01-01 Hiromi Wada Multi-functional testing method for attention ability by elaborating the target detection method and application to developmental neurotoxicology : testing for selective, sustained, shifted, and bisectional attention pdf
12_PT01-02 Bin-Le Lin Development of a user-friendly risk assessment tool for voluntary environmental risk
assessment and management by business operators
pdf pdf pdf
12_PT01-03 Takashi Morita Research for establishing new method for risk assessment of chemical toxicity using gene-modified ES cells pdf
12_PT01-04 Nobuhiro Tanuma Development of mice visualizing "Metabolic reprograming" at early phase of tumorigenesis, and its application to caricinogenicity tests pdf pdf
12_PT01-05 Takeshi BAMBA Development of metabolic profiling system for in vitro evaluation of
endocrine disruption by chemical substances
pdf pdf
12_PT01-06 Yoshimasa Takahashi Sophisticated hazard prediction by active QSAR modeling pdf pdf pdf
13_PT01-01 Yuhei Nishimura Development of in vivo fluorescent imaging of neuronal
differentiaon in zebrafish for developmental neuotoxicity testing
pdf pdf pdf pdf
13_PT01-02 Kohji Yamakage Applied research of a novel in vitro method for developmental
toxicity to facilitate the industrial utilization
pdf pdf
13_PT01-03 Kouichi Yoshinari Development of a combined in vitro/in silico system to predict and
evaluate the complex hepatotoxicity of chemical compounds.
pdf pdf pdf
15_PT01-01 Tsuyoshi Nakanishi Development of new in vivo screening method to validate the
low-dose effects induced by estrogenic chemicals using estrogen
reporter mice
pdf pdf pdf pdf
16_PT01-01 Shunichi Takeda Establishment of a comprehensive test for identifying mutagenic chemical compounds and molecular mechanisms underlying mutagenesis. pdf pdf
16_PT01-02 Yoshihiro Uesawa Construction of prediction models for toxicities induced by drugs and chemicals based on chemical structures and AOP pdf pdf pdf
17_PT01-01 FUKUDA@Junji Chip device for in vitro systemic toxicology pdf pdf pdf
17_PT01-02 Miyazaki, Wataru Development of a new screening and predicting method using cfDNA to measure the effects of environmental chemicals in whole organs and its application for fetal exposure. pdf pdf pdf
15_PT02-01 Yukari Totsuka Construction of the novel in vitro evaluation systems based on the
genotoxic mechanisms of nanomaterials
pdf pdf
17_PT02-01 Hiroyuki Tsuda Establishment of mechanism based assay protocol for hasard and carcinogenic risk of carbon based nanomaterisals. pdf pdf pdf
12_PT03-01 Akira Nakamura Development of high sensitivity in vitro assessment system of chemical-mediated hypersensitivity by using serine protease inhibitor-deficient cells.
Subtitle: Analysis of in vitro assessment for respiratory allergy
pdf pdf pdf pdf pdf pdf
13_PT03-01 Hiroyuki Kusuhara Quantitative prediction of the pharmacokinetics of chemical substances by the use of
mathematical model with considering the age-dependent functional changes of metabolic
enzymes and transporters
pdf pdf pdf
12_PT04-01 Norihide Nakada Comprehensive evaluation methods for chemicals registered in PRTR. pdf pdf pdf
12_PT04-02 Yuhei INAMORI Development of Ecosystem Risk Impact Assessment System Methods for Chemicals using Microcosm Systems pdf pdf
16_PT04-01 Kei NAKAYAMA Development of the platform to manage the monitoring data of chemicals in environment, ChemTHEATRE pdf pdf pdf
13_PT05-01 Kazumasa Hirata Development and practical verification of novel comprehensive
monitoring system for multiple contaminations of environmental
pollutants in Mekong River basin
pdf pdf pdf pdf
17_S05-01 Hiroyuki Kusuhara Development of a novel approach for analyzing the biological actions of chemicals based on the deep phenotyping method. pdf pdf pdf
18_S01-01 Masaaki Miyazawa Validation study on in vitro skin sensitization test method, EpiSensA, useing reconstructed human epidermis model pdf pdf
18_R04-01 Kamo, Masashi Exploring roles and simple estimation methods of species sensitivity distribution for deriving PNECs pdf pdf
18_R05-01 Tatarazako Norihisa Study on the contribution of microplastics to bioaccumulation and biological magnification towards fish pdf pdf
19_R01-01 FUJIBUCHI WATARU Development of rapid, accurate, and low-cost AI drug hazard assessment method by human stem cell test pdf
19_R03-01 Takayuki Yoshimoto Development of a novel alternative method for evaluation of sensitizing potential and allergenicity by measuring human T cell activation and differentiation (Key event 4) pdf
19_R05-01 Yuji Oshima Construction of pharmacokinetic model to degradated microplastic-absorpted chemicals in fish and their risk analysis pdf
19_D08-01 Shinichi KURODA Elucidation of Formation Mechanism of Microplastics pdf
20-1-11 Yuko Sekino In vitro assay for developmental and adult neurotoxicity of chemicals that bind to glutamate receptors causing learning and memory impairment
20-3-02 YAMADA Tomoya Development of a short-term in vivo assay for thyroid hormone disrupting activity in fetus/pups as prescrining for potential of developmental neurotoxicity
20-3-06 Yaichiro Kotake Evaluation Methods for toxicity using indices of developing neurons
20-3-08 Nishimura Yuhei Development of a novel neuroinflamation assay for the analysis of AOP in developmental neurotoxicity
20-3-10 Tsuyoshi Nakanishi Establishment of an adverse outcome pathway for the evaluation of developmental neurotoxicity in chemical-induced hypothyroidism
20-6-04 Naito Wataru Development of Conceptual Model for an Environmental Risk Assessment of Microplastics and a trial MP Risk Assessment for Tokyo Bay
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